North Charleston is a city in Berkeley, Charleston, and Dorchester counties in the U.S. state of South Carolina. As of the 2020 census, …North Charleston is a city in Berkeley, Charleston, and Dorchester counties in the U.S. state of South Carolina. As of the 2020 census, North Charleston had a population of 114,852, making it the third-most populous city in the state, and the 248th-most populous city in the United States. North Charleston is a principal city within the Charleston-North Charleston, SC Metropolitan Statistical Area, which had an estimated population of 849,417 in 2023.