Downtown St. Louis is the central business district of St. Louis, Missouri, the hub of tourism and entertainment, and the anchor of the St. Louis metropolitan area. The downtown is bounded by Cole Street to the north, the river front to the east, Chouteau Avenue to the south, and Tucker Boulevard to the west. The downtown is the site of many corporate h…Downtown St. Louis is the central business district of St. Louis, Missouri, the hub of tourism and entertainment, and the anchor of the St. Louis metropolitan area. The downtown is bounded by Cole Street to the north, the river front to the east, Chouteau Avenue to the south, and Tucker Boulevard to the west. The downtown is the site of many corporate headquarters, including Stifel Financial Corp., HOK, Spire Inc, and a host of other companies.